Endotoxins ƙananan ƙwayoyin cuta ne waɗanda aka samu hydrophobic lipopolysaccharides (LPS) waɗanda ke samuwa a cikin membrane na waje na ƙwayoyin cuta gram-korau.Endotoxins sun ƙunshi ainihin sarkar polysaccharide, sarƙoƙin gefe na polysaccharide O-takamaiman (O-antigen) da ladaran lipid, Lipid A, wanda ke da alhakin tasirin mai guba.Bacteria suna zubar da endotoxin da yawa akan mutuwar tantanin halitta da kuma lokacin da suke girma da rarrabuwa.Escherichia coli guda ɗaya ya ƙunshi kusan ƙwayoyin LPS miliyan biyu a kowace tantanin halitta.
Endotoxin na iya gurɓata labwares cikin sauƙi, kuma kasancewar sa na iya ba da mahimmanci ga gwaje-gwajen in vitro da a cikin vivo.Kuma ga samfuran mahaifa, samfuran parenteral da suka gurɓata tare da endotoxins ciki har da LPS na iya haifar da haɓakar zazzabi, ƙaddamar da amsa mai kumburi, girgiza, gazawar gabbai da mutuwa a cikin ɗan adam.Don samfuran dialysis, LPS za a iya canjawa wuri ta hanyar membrane tare da babban girman pore ta baya-tace daga ruwan dialysis zuwa jini, ana iya haifar da matsalolin kumburi daidai da haka.
An gano Endotoxin ta Lyophilized Amebocyte Lysate (TAL).An sadaukar da Bioendo don bincike, haɓakawa da samar da TAL reagent fiye da shekaru arba'in.Samfuran mu sun rufe duk dabarun da aka yi amfani da su don gano endotoxin, waɗanda ke da fasaha na gel-clot, dabarar turbidimetric, da fasaha na chromogenic.
Lokacin aikawa: Janairu-29-2019
